High-performance computing (HPC) is the backbone of scientific discovery, AI innovation, and real-world impact – from accelerating cancer research to training the world’s most advanced AI models. As data volumes soar and algorithms grow ever more complex, HPC delivers the power to process, simulate, and solve on a massive scale. Now, with AI demanding unprecedented levels of compute power, HPC is stepping into a new era, and Lenovo is leading the way.
Lenovo Remains the World’s #1 Supercomputer Provider
Announced at ISC 2025 today, Lenovo has retained its place as the world’s leading supercomputing provider by systems share, coming in as the #1 high-performance computing (HPC) vendor on the TOP500 list of supercomputers. By combining innovation with sustainability, like our latest Neptune liquid cooling systems, we’re helping academics and researchers alike unlock discoveries faster, more efficiently, and at lower environmental cost.
Lenovo ThinkSystems have been chosen to power a number of Green500 supercomputers also announced today, including 3 systems in the top 10, as well as North America’s #1 greenest supercomputer, and two of Germany’s top three most efficient supercomputers. The Top500 and Green500 rankings reflect our commitment to tackling some of humanity’s biggest challenges, from blackholes to blood cultures, and the crucial role of liquid cooling solutions in powering sustainable approaches to HPC, and delivering the next generation of computing performance.
Lenovo HPC in Action
The Lenovo ThinkSystem N1380 Neptune chassis, announced at Tech World, offers the next era of Neptune Water Cooling, reshaping data centre design with 100% heat removal. This empowers researchers to run server racks with more than 100 kilowatts of HPC equipment, powering simulations and other cutting-edge research to unravel scientific problems from climate change to cancer research. With open-loop, direct warm-water cooling, critical components can operate at lower temperature, enabling AI training and inference for models up to 10 trillion parameters.
As we showcase our capabilities at the International Supercomputing Conference (ISC) in Hamburg this week, we’re proud to highlight the growing community of leading institutions across EMEA that are advancing their missions with Lenovo HPC. At the University of Montpellier within the Montpellier Data Science Institute in France, 400 research laboratories with more than 10,000 researchers across all scientific disciplines are using the ISDM-MESO computing and cloud cluster, with customized environments both for experts who often use international-level equipment, and experts who have had very little access to such equipment in the past. The cluster, named after renowned scientist Isabelle Olivieri, will run off Lenovo HPC servers with 10,000 AMD cores as well as NVIDIA H100 GPUs, all cooled with full Lenovo Neptune Water Cooling technology. It includes 2.8 petabytes of high-performance WekaIO storage, interconnected by dual 200 Gb/s networks. The system is set to deliver results in healthcare research and climate-related studies, such as flood forecasting.
In Germany, the Paderborn Center for Parallel Computing is home to a newly installed Lenovo-powered supercomputer, Otus, designed to advance cutting-edge research in AI, physics, and engineering. Newly ranking at #5 in the Green500 list, and built by pro-com DATENSYSTEME on the Lenovo ThinkSystem SD655 V3 HPC system, the new cluster features eleven high-density compute racks with direct liquid cooling, which dramatically improves energy efficiency while the system still supports intensive scientific workloads. Featuring a high-performance parallel file system and state-of-the-art GPU acceleration, the cluster is optimized for complex simulations, including atomic-level interactions and AI model training. Available to researchers across Germany, this next-generation infrastructure enables new breakthroughs in everything from material science to quantum computing.
In Austria, the new MUSICA supercomputer cluster – powered by Lenovo’s HPC systems – enables groundbreaking AI and scientific research across multiple institutions. Operated by TU Wien, the cluster spans several cities and combines HPC with cloud computing to provide flexible, scalable compute power. The Viennese site alone features 112 Lenovo GPU nodes, giving researchers the ability to train complex AI models and run large-scale simulations in fields ranging from engineering to environmental science. By distributing compute resources nationally, MUSICA ensures that cutting-edge performance is accessible to researchers wherever they are. At each location the waste heat from Lenovo’s Neptune warm water-cooling technology will be reused to heat neighboring buildings or fed into the district heating network.
In Italy, Lenovo is helping to accelerate life-saving research at the European Institute of Oncology (IEO) and the Monzino Cardiology Center with an impressive 475 teraflop HPC system built on Lenovo ThinkSystem SR645 V3 and SR685a V3 servers. This HPC system is accelerating scientific research into the study of cancers, working to create predictive models which can accelerate the development of new drugs to combat the disease as well as new preventative tools. AI is accelerating the process of selecting molecules, allowing researchers to hone in on potential candidates far more rapidly. Integrated with the institutes’ Clinical DataLakes and supported by Lenovo’s DE6400F storage systems, the solution empowers researchers to process massive datasets with speed and precision, paving the way for more personalized and effective treatments for cancer and heart disease.
HPC is also helping break language barriers, with a Lenovo solution powering Lara Translate’s platform. Built by Translated, Lara is the world’s most reliable AI translator, consistently preferred by professional translators in blink tests over leading systems on real content across the most commonly used languages. Lara can now deliver extremely high-quality translation with a latency of less than a second. This means it is ideal for applications where speed is critical such as real-time customer support. Lara is 10 to 40 times faster than rivals, delivering event document translation so fast that users feel it is instantaneous. The ‘secret sauce’ is Lenovo ThinkSystem servers, built to optimize GPU performance and push latency below a single millisecond. Lenovo is adding liquid-cooling systems to reduce energy consumption and allow for higher machine density, meaning the AI operations are more sustainable and scalable.
From advancing climate science and life-saving medical research to powering real-time AI and breaking down language barriers, Lenovo HPC is at the heart of Europe’s most ambitious innovation. Our systems are not just supporting research, they’re accelerating it, sustainably and at scale.
Visit us at the International Supercomputing Conference in Hamburg from June 10-13, booth D30, to discover how smarter infrastructure is shaping a smarter, more resilient future.
